Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

BACKGROUND: Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics. The aim of this study was to determine the role of organic-anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic...

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Autores principales: Trdan Lušin, Tina, Stieger, Bruno, Marc, Janja, Mrhar, Aleš, Trontelj, Jurij, Zavratnik, Andrej, Ostanek, Barbara
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476964/
https://ncbi.nlm.nih.gov/pubmed/22533838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-76
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