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Constant Domain-regulated Antibody Catalysis
Some antibodies contain variable (V) domain catalytic sites. We report the superior amide and peptide bond-hydrolyzing activity of the same heavy and light chain V domains expressed in the IgM constant domain scaffold compared with the IgG scaffold. The superior catalytic activity of recombinant IgM...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3476277/ https://ncbi.nlm.nih.gov/pubmed/22948159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401075 |
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