Deficient synthesis of class-switched, HIV-neutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen

OBJECTIVE: HIV is vulnerable to antibodies that recognize a linear CD4 binding site epitope of gp120 (C(LIN)), but inducing C(LIN)-directed antibody synthesis by traditional vaccine principles is difficult. We wished to understand the basis for deficient C(LIN)-directed antibody synthesis and valida...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:AIDS
Main Authors: Planque, Stephanie A., Mitsuda, Yukie, Chitsazzadeh, Vida, Gorantla, Santhi, Poluektova, Larisa, Nishiyama, Yasuhiro, Ochsenbauer, Christina, Morris, Mary-Kate, Sapparapu, Gopal, Hanson, Carl V., Massey, Richard J., Paul, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573643/
https://ncbi.nlm.nih.gov/pubmed/25022597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000392
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados