Deficient synthesis of class-switched, HIV-neutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen

OBJECTIVE: HIV is vulnerable to antibodies that recognize a linear CD4 binding site epitope of gp120 (C(LIN)), but inducing C(LIN)-directed antibody synthesis by traditional vaccine principles is difficult. We wished to understand the basis for deficient C(LIN)-directed antibody synthesis and valida...

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Gepubliceerd in:AIDS
Hoofdauteurs: Planque, Stephanie A., Mitsuda, Yukie, Chitsazzadeh, Vida, Gorantla, Santhi, Poluektova, Larisa, Nishiyama, Yasuhiro, Ochsenbauer, Christina, Morris, Mary-Kate, Sapparapu, Gopal, Hanson, Carl V., Massey, Richard J., Paul, Sudhir
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573643/
https://ncbi.nlm.nih.gov/pubmed/25022597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000392
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