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Neutralization of genetically diverse HIV-1 strains by IgA antibodies to the gp120 CD4 binding site from long-term survivors of HIV infection
OBJECTIVE: To identify an HIV epitope suitable for vaccine development. DESIGN: Diverse HIV-1 strains express few structurally constant regions on their surface vulnerable to neutralizing antibodies. The mostly-conserved CD4 binding site (CD4BS) of gp120 is essential for host cell binding and infect...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881561/ https://ncbi.nlm.nih.gov/pubmed/20186035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283376e88 |
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