Neutralization of genetically diverse HIV-1 strains by IgA antibodies to the gp120 CD4 binding site from long-term survivors of HIV infection

OBJECTIVE: To identify an HIV epitope suitable for vaccine development. DESIGN: Diverse HIV-1 strains express few structurally constant regions on their surface vulnerable to neutralizing antibodies. The mostly-conserved CD4 binding site (CD4BS) of gp120 is essential for host cell binding and infect...

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Main Authors: Planque, Stephanie, Salas, Maria, Mitsuda, Yukie, Sienczyk, Marcin, Escobar, Miguel A., Mooney, Jason P., Morris, Mary-Kate, Nishiyama, Yasuhiro, Ghosh, Dipanjan, Kumar, Amit, Gao, Feng, Hanson, Carl V., Paul, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881561/
https://ncbi.nlm.nih.gov/pubmed/20186035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283376e88
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