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Toward Effective HIV Vaccination: INDUCTION OF BINARY EPITOPE REACTIVE ANTIBODIES WITH BROAD HIV NEUTRALIZING ACTIVITY
We describe murine monoclonal antibodies (mAbs) raised by immunization with an electrophilic gp120 analog (E-gp120) expressing the rare ability to neutralize genetically heterologous human immunodeficiency virus (HIV) strains. Unlike gp120, E-gp120 formed covalent oligomers. The reactivity of gp120...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781617/ https://ncbi.nlm.nih.gov/pubmed/19726674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032185 |
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