Toward Effective HIV Vaccination: INDUCTION OF BINARY EPITOPE REACTIVE ANTIBODIES WITH BROAD HIV NEUTRALIZING ACTIVITY

We describe murine monoclonal antibodies (mAbs) raised by immunization with an electrophilic gp120 analog (E-gp120) expressing the rare ability to neutralize genetically heterologous human immunodeficiency virus (HIV) strains. Unlike gp120, E-gp120 formed covalent oligomers. The reactivity of gp120...

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Bibliographic Details
Main Authors: Nishiyama, Yasuhiro, Planque, Stephanie, Mitsuda, Yukie, Nitti, Giovanni, Taguchi, Hiroaki, Jin, Lei, Symersky, Jindrich, Boivin, Stephane, Sienczyk, Marcin, Salas, Maria, Hanson, Carl V., Paul, Sudhir
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781617/
https://ncbi.nlm.nih.gov/pubmed/19726674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032185
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