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Metal-Dependent Amyloid β-Degrading Catalytic Antibody Construct
Catalytic antibodies (catabodies) that degrade target antigens rapidly are rare. We describe the metal-dependence of catabody construct 2E6, an engineered heterodimer of immunoglobulin light chain variable domains that hydrolyzes amyloid β peptides (Aβ) specifically. In addition to the electrophilic...
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| Publicado no: | J Biotechnol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4512298/ https://ncbi.nlm.nih.gov/pubmed/24698848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiotec.2014.03.026 |
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