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Exceptional Amyloid β Peptide Hydrolyzing Activity of Nonphysiological Immunoglobulin Variable Domain Scaffolds

Nucleophilic sites in the paired variable domains of the light and heavy chains (V(L) and V(H) domains) of Ig can catalyze peptide bond hydrolysis. Amyloid β (Aβ)-binding Igs are under consideration for immunotherapy of Alzheimer disease. We searched for Aβ-hydrolyzing human IgV domains (IgVs) in a...

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Detalhes bibliográficos
Main Authors: Taguchi, Hiroaki, Planque, Stephanie, Sapparapu, Gopal, Boivin, Stephane, Hara, Mariko, Nishiyama, Yasuhiro, Paul, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606003/
https://ncbi.nlm.nih.gov/pubmed/18974093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806766200
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