Exceptional Amyloid β Peptide Hydrolyzing Activity of Nonphysiological Immunoglobulin Variable Domain Scaffolds

Nucleophilic sites in the paired variable domains of the light and heavy chains (V(L) and V(H) domains) of Ig can catalyze peptide bond hydrolysis. Amyloid β (Aβ)-binding Igs are under consideration for immunotherapy of Alzheimer disease. We searched for Aβ-hydrolyzing human IgV domains (IgVs) in a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Taguchi, Hiroaki, Planque, Stephanie, Sapparapu, Gopal, Boivin, Stephane, Hara, Mariko, Nishiyama, Yasuhiro, Paul, Sudhir
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
Enzyme Catalysis and Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606003/
https://ncbi.nlm.nih.gov/pubmed/18974093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806766200
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