Antigen-specific Proteolysis by Hybrid Antibodies Containing Promiscuous Proteolytic Light Chains Paired with an Antigen-binding Heavy Chain

The antigen recognition site of antibodies consists of the heavy and light chain variable domains (V(L) and V(H) domains). V(L) domains catalyze peptide bond hydrolysis independent of V(H) domains (Mei, S., Mody, B., Eklund, S. H., and Paul, S. (1991) J. Biol. Chem. 266, 15571–15574). V(H) domains b...

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Bibliografiska uppgifter
Huvudupphovsmän: Sapparapu, Gopal, Planque, Stephanie A., Nishiyama, Yasuhiro, Foung, Steven K., Paul, Sudhir
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Enzyme Catalysis and Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782051/
https://ncbi.nlm.nih.gov/pubmed/19542217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011858
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