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Antigen-specific Proteolysis by Hybrid Antibodies Containing Promiscuous Proteolytic Light Chains Paired with an Antigen-binding Heavy Chain

The antigen recognition site of antibodies consists of the heavy and light chain variable domains (V(L) and V(H) domains). V(L) domains catalyze peptide bond hydrolysis independent of V(H) domains (Mei, S., Mody, B., Eklund, S. H., and Paul, S. (1991) J. Biol. Chem. 266, 15571–15574). V(H) domains b...

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Bibliografische gegevens
Hoofdauteurs: Sapparapu, Gopal, Planque, Stephanie A., Nishiyama, Yasuhiro, Foung, Steven K., Paul, Sudhir
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782051/
https://ncbi.nlm.nih.gov/pubmed/19542217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011858
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