Antigen-specific Proteolysis by Hybrid Antibodies Containing Promiscuous Proteolytic Light Chains Paired with an Antigen-binding Heavy Chain

The antigen recognition site of antibodies consists of the heavy and light chain variable domains (V(L) and V(H) domains). V(L) domains catalyze peptide bond hydrolysis independent of V(H) domains (Mei, S., Mody, B., Eklund, S. H., and Paul, S. (1991) J. Biol. Chem. 266, 15571–15574). V(H) domains b...

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Detalhes bibliográficos
Main Authors: Sapparapu, Gopal, Planque, Stephanie A., Nishiyama, Yasuhiro, Foung, Steven K., Paul, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782051/
https://ncbi.nlm.nih.gov/pubmed/19542217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011858
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