Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease

Immunoglobulins (Igs) that bind amyloid β peptide (Aβ) are under clinical trials for immunotherapy of Alzheimer disease (AD). We have identified IgMs and recombinant Ig fragments that hydrolyze Aβ. Hydrolysis of peripheral Aβ by the IgMs may induce increased Aβ release from the brain. The catalytic...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Taguchi, Hiroaki, Planque, Stephanie, Nishiyama, Yasuhiro, Szabo, Paul, Weksler, Marc E., Friedland, Robert P., Paul, Sudhir
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430036/
https://ncbi.nlm.nih.gov/pubmed/18486927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.autrev.2008.03.004
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky