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Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease
Immunoglobulins (Igs) that bind amyloid β peptide (Aβ) are under clinical trials for immunotherapy of Alzheimer disease (AD). We have identified IgMs and recombinant Ig fragments that hydrolyze Aβ. Hydrolysis of peripheral Aβ by the IgMs may induce increased Aβ release from the brain. The catalytic...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2430036/ https://ncbi.nlm.nih.gov/pubmed/18486927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.autrev.2008.03.004 |
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