Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease

Immunoglobulins (Igs) that bind amyloid β peptide (Aβ) are under clinical trials for immunotherapy of Alzheimer disease (AD). We have identified IgMs and recombinant Ig fragments that hydrolyze Aβ. Hydrolysis of peripheral Aβ by the IgMs may induce increased Aβ release from the brain. The catalytic...

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Detaylı Bibliyografya
Asıl Yazarlar: Taguchi, Hiroaki, Planque, Stephanie, Nishiyama, Yasuhiro, Szabo, Paul, Weksler, Marc E., Friedland, Robert P., Paul, Sudhir
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430036/
https://ncbi.nlm.nih.gov/pubmed/18486927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.autrev.2008.03.004
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