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Deficient synthesis of class-switched, HIV-neutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen
OBJECTIVE: HIV is vulnerable to antibodies that recognize a linear CD4 binding site epitope of gp120 (C(LIN)), but inducing C(LIN)-directed antibody synthesis by traditional vaccine principles is difficult. We wished to understand the basis for deficient C(LIN)-directed antibody synthesis and valida...
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| Publicat a: | AIDS |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4573643/ https://ncbi.nlm.nih.gov/pubmed/25022597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000392 |
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