Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma

No curative treatment exists for glioblastoma, with median survival times of less than 2 years from diagnosis. As an approach to develop immune-based therapies for glioblastoma, we sought to target antigens expressed in glioma stem cells (GSCs). GSCs have multiple properties that make them significa...

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Bibliographische Detailangaben
Hauptverfasser: Morgan, Richard A., Johnson, Laura A., Davis, Jeremy L., Zheng, Zhili, Woolard, Kevin D., Reap, Elizabeth A., Feldman, Steven A., Chinnasamy, Nachimuthu, Kuan, Chien-Tsun, Song, Hua, Zhang, Wei, Fine, Howard A., Rosenberg, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2012
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472555/
https://ncbi.nlm.nih.gov/pubmed/22780919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.041
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