Selective amplification of polymorphic dihydrofolate reductase gene loci in Chinese hamster lung cells.
A series of antifolate-resistant Chinese hamster lung sublines that overproduce either a Mr 20,000 or a Mr 21,000 class of dihydrofolate reductase (DHFR; tetrahydrofolate dehydrogenase; 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3), known to contain amplified DHFR genes, has been analyz...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1982
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6184719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.22.6961 |
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