Selective amplification of polymorphic dihydrofolate reductase gene loci in Chinese hamster lung cells.

A series of antifolate-resistant Chinese hamster lung sublines that overproduce either a Mr 20,000 or a Mr 21,000 class of dihydrofolate reductase (DHFR; tetrahydrofolate dehydrogenase; 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3), known to contain amplified DHFR genes, has been analyz...

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Hlavní autoři: Lewis, J A, Davide, J P, Melera, P W
Médium: Artigo
Jazyk:Inglês
Vydáno: 1982
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC347254/
https://ncbi.nlm.nih.gov/pubmed/6184719
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