SYNTHESIS AND BIOLOGICAL EVALUATION OF BIARYL ANALOGS OF ANTITUBULIN COMPOUNDS

This paper reports the synthesis of methanones and esters bearing different substitution patterns as spacer groups between aromatic rings. This series of compounds can be considered phenstatin analogs. Two of the newly synthesized compounds, 5a and 5c, strongly inhibited tubulin polymerization and t...

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Bibliografiske detaljer
Main Authors: Tozatti, Camila Santos Suniga, Khodyuk, Rejane Gonçalves Diniz, da Silva, Adriano Olimpio, dos Santos, Edson dos Anjos, de Lima, Marcos Serrou do Amaral e Dênis Pires, Hamel, Ernest
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472429/
https://ncbi.nlm.nih.gov/pubmed/23087491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S0100-40422012000900010
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