A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds

BACKGROUND: Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequently ends in cell death. We set out to identify s...

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Autori principali: Screpanti, Emanuela, Santaguida, Stefano, Nguyen, Tam, Silvestri, Romano, Gussio, Rick, Musacchio, Andrea, Hamel, Ernest, De Wulf, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904697/
https://ncbi.nlm.nih.gov/pubmed/20657644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011603
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