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A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds
BACKGROUND: Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequently ends in cell death. We set out to identify s...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904697/ https://ncbi.nlm.nih.gov/pubmed/20657644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011603 |
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