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Evading Pgp activity in drug-resistant cancer cells: a structural and functional study of antitubulin furan metotica compounds
Tumor resistance to antitubulin drugs resulting from Pgp drug-efflux activity, increased expression of the βIII tubulin isotype, and alterations in the drug-binding sites are major obstacles in cancer therapy. Consequently, novel antitubulin drugs that overcome these challenges are of substantial in...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349764/ https://ncbi.nlm.nih.gov/pubmed/22442310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-1018 |
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