Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity

We have devised a procedure for the synthesis of analogs of combretastatin A-4 (CA-4) containing sulfur and selenium atoms as spacer groups between the aromatic rings. CA-4 is well known for its potent activity as an inhibitor of tubulin polymerization, and its prodrugs combretastatin A-4 phosphate...

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Autores principales: dos Santos, Edson dos A., Hamel, Ernest, Bai, Ruoli, Burnett, James C., Tozatti, Camila Santos Suniga, Bogo, Danielle, Perdomo, Renata T., Antunes, Alexandra M. M., Marques, M. Matilde, Matos, Maria de F. C., de Lima, Dênis P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774136/
https://ncbi.nlm.nih.gov/pubmed/23810282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.009
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