Orthogonal activation of the reengineered A(3) adenosine receptor (neoceptor) using tailored nucleoside agonists

An alternative approach to overcome the inherent lack of specificity of conventional agonist therapy can be the reengineering of the GPCRs and their agonists. A reengineered receptor (neoceptor) could be selectively activated by a modified agonist, but not by the endogenous agonist. Assisted by rhod...

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Detalhes bibliográficos
Main Authors: Gao, Zhan-Guo, Duong, Heng T., Sonin, Tatiana, Kim, Soo-Kyung, Van Rompaey, Philippe, Van Calenbergh, Serge, Mamedova, Liaman, Kim, Hea Ok, Kim, Myong Jung, Kim, Ae Yil, Liang, Bruce T., Jeong, Lak Shin, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471142/
https://ncbi.nlm.nih.gov/pubmed/16640329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050968b
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