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NEOCEPTORS: REENGINEERING GPCRs TO RECOGNIZE TAILORED LIGANDS
Efforts to model and reengineer the putative binding sites of G protein-coupled receptors (GPCRs) have led to an approach to combining small molecule “classical” medicinal chemistry and gene therapy. By this approach, complementary structural changes, for example, based on novel ionic or H bonds, ar...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2495023/ https://ncbi.nlm.nih.gov/pubmed/17280720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2007.01.006 |
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