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Neoceptor Concept Based on Molecular Complementarity in GPCRs: A Mutant Adenosine A(3) Receptor with Selectively Enhanced Affinity for Amine-Modified Nucleosides
Adenosine A(3) receptors are of interest in the treatment of cardiac ischemia, inflammation, and neurodegenerative diseases. In an effort to create a unique receptor mutant that would be activated by tailor-made synthetic ligands, we mutated the human A(3) receptor at the site of a critical His resi...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413945/ https://ncbi.nlm.nih.gov/pubmed/11708915 |
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