Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position

We studied the structural determinants of binding affinity and efficacy of adenosine receptor (AR) agonists. Substituents at the 2-position of adenosine were combined with N(6)-substitutions known to enhance human A(3)AR affinity. Selectivity of binding of the analogues and their functional effects...

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Detalhes bibliográficos
Main Authors: Ohno, Michihiro, Gao, Zhan-Guo, Van Rompaey, Philippe, Tchilibon, Susanna, Kim, Soo-Kyung, Harris, Brian A., Gross, Ariel S., Duong, Heng T., Van Calenbergh, Serge, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463103/
https://ncbi.nlm.nih.gov/pubmed/15142558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2004.03.031
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