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Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position
We studied the structural determinants of binding affinity and efficacy of adenosine receptor (AR) agonists. Substituents at the 2-position of adenosine were combined with N(6)-substitutions known to enhance human A(3)AR affinity. Selectivity of binding of the analogues and their functional effects...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2004
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463103/ https://ncbi.nlm.nih.gov/pubmed/15142558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2004.03.031 |
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