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Exploring human adenosine A(3) receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety
In this paper we investigated the influence on affinity, selectivity and intrinsic activity upon modification of the adenosine agonist scaffold at the 3′- and 5′-positions of the ribofuranosyl moiety and the 2- and N(6)-positions of the purine base. This resulted in the synthesis of various analogue...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460517/ https://ncbi.nlm.nih.gov/pubmed/15670905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2004.11.044 |
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