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Exploring human adenosine A(3) receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety
In this paper we investigated the influence on affinity, selectivity and intrinsic activity upon modification of the adenosine agonist scaffold at the 3′- and 5′-positions of the ribofuranosyl moiety and the 2- and N(6)-positions of the purine base. This resulted in the synthesis of various analogue...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460517/ https://ncbi.nlm.nih.gov/pubmed/15670905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2004.11.044 |
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