Structural determinants of efficacy at A(3) adenosine receptors: modification of the ribose moiety

We have found previously that structural features of adenosine derivatives, particularly at the N(6)- and 2-positions of adenine, determine the intrinsic efficacy as A(3) adenosine receptor (AR) agonists. Here, we have probed this phenomenon with respect to the ribose moiety using a series of ribose...

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Detalhes bibliográficos
Main Authors: Gao, Zhan-Guo, Jeong, Lak Shin, Moon, Hyung Ryong, Kim, Hea Ok, Choi, Won Jun, Shin, Dae Hong, Elhalem, Eleonora, Comin, Maria J., Melman, Neli, Mamedova, Liaman, Gross, Ariel S., Rodriguez, Juan B., Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150582/
https://ncbi.nlm.nih.gov/pubmed/15104242
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