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2-Triazole-Substituted Adenosines: A New Class of Selective A(3) Adenosine Receptor Agonists, Partial Agonists, and Antagonists
“Click chemistry” was explored to synthesize two series of 2-(1,2,3-triazolyl)adenosine derivatives (1–14). Binding affinity at the human A(1), A(2A), and A(3)ARs (adenosine receptors) and relative efficacy at the A(3)AR were determined. Some triazol-1-yl analogues showed A(3)AR affinity in the low...
Shranjeno v:
| izdano v: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4968940/ https://ncbi.nlm.nih.gov/pubmed/17149867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0608208 |
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