Probing the Binding Site of the A(1) Adenosine Receptor Reengineered for Orthogonal Recognition by Tailored Nucleosides

His272 (7.43) in the seventh transmembrane domain (TM7) of the human A(3) adenosine receptor (AR) interacts with the 3′ position of nucleosides, based on selective affinity enhancement at a H272E mutant A(3) AR (neoceptor) of 3′-ureido, but not 3′-OH, adenosine analogues. Here, mutation of the analo...

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Главные авторы: Palaniappan, Krishnan K., Gao, Zhan-Guo, Ivanov, Andrei A., Greaves, Rebecca, Adachi, Hayamitsu, Besada, Pedro, Kim, Hea Ok, Kim, Ae Yil, Choe, Seung Ah, Jeong, Lak Shin, Jacobson, Kenneth A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140710/
https://ncbi.nlm.nih.gov/pubmed/17542617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7001828
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