Probing the Binding Site of the A(1) Adenosine Receptor Reengineered for Orthogonal Recognition by Tailored Nucleosides

His272 (7.43) in the seventh transmembrane domain (TM7) of the human A(3) adenosine receptor (AR) interacts with the 3′ position of nucleosides, based on selective affinity enhancement at a H272E mutant A(3) AR (neoceptor) of 3′-ureido, but not 3′-OH, adenosine analogues. Here, mutation of the analo...

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Autori principali: Palaniappan, Krishnan K., Gao, Zhan-Guo, Ivanov, Andrei A., Greaves, Rebecca, Adachi, Hayamitsu, Besada, Pedro, Kim, Hea Ok, Kim, Ae Yil, Choe, Seung Ah, Jeong, Lak Shin, Jacobson, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140710/
https://ncbi.nlm.nih.gov/pubmed/17542617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7001828
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