Probing the Binding Site of the A(1) Adenosine Receptor Reengineered for Orthogonal Recognition by Tailored Nucleosides

His272 (7.43) in the seventh transmembrane domain (TM7) of the human A(3) adenosine receptor (AR) interacts with the 3′ position of nucleosides, based on selective affinity enhancement at a H272E mutant A(3) AR (neoceptor) of 3′-ureido, but not 3′-OH, adenosine analogues. Here, mutation of the analo...

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Autores principales: Palaniappan, Krishnan K., Gao, Zhan-Guo, Ivanov, Andrei A., Greaves, Rebecca, Adachi, Hayamitsu, Besada, Pedro, Kim, Hea Ok, Kim, Ae Yil, Choe, Seung Ah, Jeong, Lak Shin, Jacobson, Kenneth A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140710/
https://ncbi.nlm.nih.gov/pubmed/17542617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7001828
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