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Structure-Activity Relationships of 2,N(6),5′-Substituted Adenosine Derivatives with Potent Activity at the A(2B) Adenosine Receptor

2, N(6), and/or 5′ substituted adenosine derivatives were synthesized via alkylation of 2-oxypurine nucleosides leading to 2-aralkylether derivatives. 2-(3-(Indolyl)ethyloxy)adenosine 17 was found to be a potent agonist of the human A(2B)AR in both binding and cAMP assays. Simplification, altered co...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Adachi, Hayamitsu, Palaniappan, Krishnan K., Ivanov, Andrei A., Bergman, Nathaniel, Gao, Zhan-Guo, Jacobson, Kenneth A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405160/
https://ncbi.nlm.nih.gov/pubmed/17378544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061278q
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