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Structure-Activity Relationships of 2,N(6),5′-Substituted Adenosine Derivatives with Potent Activity at the A(2B) Adenosine Receptor
2, N(6), and/or 5′ substituted adenosine derivatives were synthesized via alkylation of 2-oxypurine nucleosides leading to 2-aralkylether derivatives. 2-(3-(Indolyl)ethyloxy)adenosine 17 was found to be a potent agonist of the human A(2B)AR in both binding and cAMP assays. Simplification, altered co...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2007
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3405160/ https://ncbi.nlm.nih.gov/pubmed/17378544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061278q |
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