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Probing Distal Regions of the A(2B) Adenosine Receptor by Quantitative Structure-Activity Relationship Modeling of Known and Novel Agonists

The binding modes at the A(2B) adenosine receptor (AR) of 72 derivatives of adenosine and its 5’-N-methyluronamide with diverse substitutions at the 2 and N(6) positions were studied using a molecular modeling approach. The compounds in their receptor-docked conformations were used to build CoMFA an...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Ivanov, Andrei A., Wang, Ben, Klutz, Athena M., Chen, Vincent L., Gao, Zhan-Guo, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540094/
https://ncbi.nlm.nih.gov/pubmed/18321038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701442d
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