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Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design
A new series of phosphodiesterase-9 (PDE9) inhibitors that contain a scaffold of 6-amino-pyrazolopyrimidinone have been discovered by a combination of structure-based design and computational docking. This procedure significantly saved load of chemical synthesis and is an effective method for the di...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469756/ https://ncbi.nlm.nih.gov/pubmed/22985069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301189c |
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