HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

The acquisition of drug-resistance mutations by infectious pathogens remains a pressing health concern, and the development of strategies to combat this threat is a priority. Here we have applied a general strategy, inverse design using the substrate envelope, to develop inhibitors of HIV-1 protease...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Altman, Michael D., Ali, Akbar, Reddy, G. S. Kiran Kumar, Nalam, Madhavi N. L., Anjum, Saima Ghafoor, Cao, Hong, Chellappan, Sripriya, Kairys, Visvaldas, Fernandes, Miguel X., Gilson, Michael K., Schiffer, Celia A., Rana, Tariq M., Tidor, Bruce
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465729/
https://ncbi.nlm.nih.gov/pubmed/18412349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja076558p
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