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Structure-Based Design, Synthesis and Structure-Activity Relationship Studies of HIV-1 Protease Inhibitors Incorporating Phenyloxazolidinones

A series of new HIV-1 protease inhibitors with the hydroxyethylamine core and different phenyloxazolidinone P2 ligands were designed and synthesized. Variation of phenyl substitutions at the P2 and P2′ moieties significantly affected the inhibitors’ binding affinity and antiviral potency. In general...

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書誌詳細
主要な著者: Ali, Akbar, Kiran Kumar Reddy, G. S., Nalam, Madhavi N. L., Anjum, Saima Ghafoor, Cao, Hong, Schiffer, Celia A., Rana, Tariq M.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996262/
https://ncbi.nlm.nih.gov/pubmed/20958050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1008743
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