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Structure-Based Design, Synthesis and Structure-Activity Relationship Studies of HIV-1 Protease Inhibitors Incorporating Phenyloxazolidinones
A series of new HIV-1 protease inhibitors with the hydroxyethylamine core and different phenyloxazolidinone P2 ligands were designed and synthesized. Variation of phenyl substitutions at the P2 and P2′ moieties significantly affected the inhibitors’ binding affinity and antiviral potency. In general...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996262/ https://ncbi.nlm.nih.gov/pubmed/20958050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1008743 |
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