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Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2′ Ligands in Pseudosymmetric Dipeptide Isosteres

A series of novel HIV-1 protease inhibitors based on two pseudosymmetric dipeptide isosteres have been synthesized and evaluated. The inhibitors were designed by incorporating N-phenyloxazolidinone-5-carboxamides into the hydroxyethylene and (hydroxyethyl)hydrazine dipeptide isosteres as P2 and P2′...

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Bibliografiske detaljer
Main Authors: Kiran Kumar Reddy, G. S., Ali, Akbar, Nalam, Madhavi N. L., Anjum, Saima Ghafoor, Cao, Hong, Nathans, Robin S., Schiffer, Celia A., Rana, Tariq M.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862176/
https://ncbi.nlm.nih.gov/pubmed/17696512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070284z
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