HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

The acquisition of drug-resistance mutations by infectious pathogens remains a pressing health concern, and the development of strategies to combat this threat is a priority. Here we have applied a general strategy, inverse design using the substrate envelope, to develop inhibitors of HIV-1 protease...

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Autors principals: Altman, Michael D., Ali, Akbar, Reddy, G. S. Kiran Kumar, Nalam, Madhavi N. L., Anjum, Saima Ghafoor, Cao, Hong, Chellappan, Sripriya, Kairys, Visvaldas, Fernandes, Miguel X., Gilson, Michael K., Schiffer, Celia A., Rana, Tariq M., Tidor, Bruce
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465729/
https://ncbi.nlm.nih.gov/pubmed/18412349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja076558p
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