HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

The acquisition of drug-resistance mutations by infectious pathogens remains a pressing health concern, and the development of strategies to combat this threat is a priority. Here we have applied a general strategy, inverse design using the substrate envelope, to develop inhibitors of HIV-1 protease...

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Detalhes bibliográficos
Main Authors: Altman, Michael D., Ali, Akbar, Reddy, G. S. Kiran Kumar, Nalam, Madhavi N. L., Anjum, Saima Ghafoor, Cao, Hong, Chellappan, Sripriya, Kairys, Visvaldas, Fernandes, Miguel X., Gilson, Michael K., Schiffer, Celia A., Rana, Tariq M., Tidor, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465729/
https://ncbi.nlm.nih.gov/pubmed/18412349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja076558p
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