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Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds
[Image: see text] Acquired resistance to therapeutic agents is a significant barrier to the development of clinically effective treatments for diseases in which evolution occurs on clinical time scales, frequently arising from target mutations. We previously reported a general strategy to design eff...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical
Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3833293/ https://ncbi.nlm.nih.gov/pubmed/23952265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400468c |
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