Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

Drug resistance mutations in HIV-1 protease selectively alter inhibitor binding without significantly affecting substrate recognition and cleavage. This alteration in molecular recognition led us to develop the substrate-envelope hypothesis which predicts that HIV-1 protease inhibitors that fit with...

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Hlavní autoři: Nalam, Madhavi N. L., Ali, Akbar, Altman, Michael D., Reddy, G. S. Kiran Kumar, Chellappan, Sripriya, Kairys, Visvaldas, Özen, Ayşegül, Cao, Hong, Gilson, Michael K., Tidor, Bruce, Rana, Tariq M., Schiffer, Celia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863851/
https://ncbi.nlm.nih.gov/pubmed/20237088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02531-09
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