Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

Drug resistance mutations in HIV-1 protease selectively alter inhibitor binding without significantly affecting substrate recognition and cleavage. This alteration in molecular recognition led us to develop the substrate-envelope hypothesis which predicts that HIV-1 protease inhibitors that fit with...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Nalam, Madhavi N. L., Ali, Akbar, Altman, Michael D., Reddy, G. S. Kiran Kumar, Chellappan, Sripriya, Kairys, Visvaldas, Özen, Ayşegül, Cao, Hong, Gilson, Michael K., Tidor, Bruce, Rana, Tariq M., Schiffer, Celia A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863851/
https://ncbi.nlm.nih.gov/pubmed/20237088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02531-09
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados