Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

Drug resistance mutations in HIV-1 protease selectively alter inhibitor binding without significantly affecting substrate recognition and cleavage. This alteration in molecular recognition led us to develop the substrate-envelope hypothesis which predicts that HIV-1 protease inhibitors that fit with...

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Hauptverfasser: Nalam, Madhavi N. L., Ali, Akbar, Altman, Michael D., Reddy, G. S. Kiran Kumar, Chellappan, Sripriya, Kairys, Visvaldas, Özen, Ayşegül, Cao, Hong, Gilson, Michael K., Tidor, Bruce, Rana, Tariq M., Schiffer, Celia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863851/
https://ncbi.nlm.nih.gov/pubmed/20237088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02531-09
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