Additivity in the Analysis and Design of HIV Protease Inhibitors

We explore the applicability of an additive treatment of substituent effects to the analysis and design of HIV protease inhibitors. Affinity data for a set of inhibitors with a common chemical framework were analyzed to provide estimates of the free energy contribution of each chemical substituent....

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Detalhes bibliográficos
Main Authors: Jorissen, Robert N., Kiran Kumar Reddy, G. S., Ali, Akbar, Altman, Michael D., Chellappan, Sripriya, Anjum, Saima G., Tidor, Bruce, Schiffer, Celia A., Rana, Tariq M., Gilson, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715819/
https://ncbi.nlm.nih.gov/pubmed/19193159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8009525
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