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Additivity in the Analysis and Design of HIV Protease Inhibitors
We explore the applicability of an additive treatment of substituent effects to the analysis and design of HIV protease inhibitors. Affinity data for a set of inhibitors with a common chemical framework were analyzed to provide estimates of the free energy contribution of each chemical substituent....
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715819/ https://ncbi.nlm.nih.gov/pubmed/19193159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8009525 |
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