Additivity in the Analysis and Design of HIV Protease Inhibitors

We explore the applicability of an additive treatment of substituent effects to the analysis and design of HIV protease inhibitors. Affinity data for a set of inhibitors with a common chemical framework were analyzed to provide estimates of the free energy contribution of each chemical substituent....

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Библиографические подробности
Главные авторы: Jorissen, Robert N., Kiran Kumar Reddy, G. S., Ali, Akbar, Altman, Michael D., Chellappan, Sripriya, Anjum, Saima G., Tidor, Bruce, Schiffer, Celia A., Rana, Tariq M., Gilson, Michael K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715819/
https://ncbi.nlm.nih.gov/pubmed/19193159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8009525
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