Design, Synthesis, Biological and Structural Evaluations of Novel HIV-1 Protease Inhibitors to Combat Drug Resistance

A series of new HIV-1 protease inhibitors (PIs) were designed using a general strategy that combines computational structure-based design with substrate-envelope constraints. The PIs incorporate various alcohol-derived P2 carbamates with acyclic and cyclic heteroatomic functionalities into the (R)-h...

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Main Authors: Parai, Maloy Kumar, Huggins, David J., Cao, Hong, Nalam, Madhavi N. L., Ali, Akbar, Schiffer, Celia A., Tidor, Bruce, Rana, Tariq M.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409094/
https://ncbi.nlm.nih.gov/pubmed/22708897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300238h
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