Phase II Trial of Intravenous Administration of Reolysin(®) (Reovirus Serotype-3-dearing Strain) in Patients with Metastatic Melanoma

Reovirus, a replication competent RNA virus, has preclinical activity against melanoma lines and xenografts. We conducted a phase II trial of reovirus in metastatic melanoma patients. Patients received 3 × 10(10) TCID50 on days 1–5 of each 28 day cycle, administered intravenously. Twenty-one eligibl...

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Bibliografiska uppgifter
Huvudupphovsmän: Galanis, Evanthia, Markovic, Svetomir N, Suman, Vera J, Nuovo, Gerard J, Vile, Richard G, Kottke, Timothy J, Nevala, Wendy K, Thompson, Michael A, Lewis, Jean E, Rumilla, Kandelaria M, Roulstone, Victoria, Harrington, Kevin, Linette, Gerald P, Maples, William J, Coffey, Matt, Zwiebel, James, Kendra, Kari
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2012
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464629/
https://ncbi.nlm.nih.gov/pubmed/22871663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.146
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