Phase II Trial of Intravenous Administration of Reolysin(®) (Reovirus Serotype-3-dearing Strain) in Patients with Metastatic Melanoma

Reovirus, a replication competent RNA virus, has preclinical activity against melanoma lines and xenografts. We conducted a phase II trial of reovirus in metastatic melanoma patients. Patients received 3 × 10(10) TCID50 on days 1–5 of each 28 day cycle, administered intravenously. Twenty-one eligibl...

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Bibliografiske detaljer
Main Authors: Galanis, Evanthia, Markovic, Svetomir N, Suman, Vera J, Nuovo, Gerard J, Vile, Richard G, Kottke, Timothy J, Nevala, Wendy K, Thompson, Michael A, Lewis, Jean E, Rumilla, Kandelaria M, Roulstone, Victoria, Harrington, Kevin, Linette, Gerald P, Maples, William J, Coffey, Matt, Zwiebel, James, Kendra, Kari
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464629/
https://ncbi.nlm.nih.gov/pubmed/22871663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.146
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