The combination of intravenous Reolysin and gemcitabine induces reovirus replication and endoplasmic reticular stress in a patient with KRAS-activated pancreatic cancer

BACKGROUND: Activating mutations in RAS are present in the majority of pancreatic cancer cases and represent an ideal therapeutic target. Reolysin is a proprietary formulation of oncolytic reovirus that is currently being evaluated in multiple clinical trials due to its ability to selectively replic...

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Udgivet i:BMC Cancer
Main Authors: Mahalingam, Devalingam, Patel, Sukeshi, Nuovo, Gerard, Gill, George, Selvaggi, Giovanni, Coffey, Matt, Nawrocki, Steffan T.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Case Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496814/
https://ncbi.nlm.nih.gov/pubmed/26156229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1518-0
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