Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides

We used a combination of fluorescence, circular dichroism (CD), and NMR spectroscopies in conjunction with size exclusion chromatography to help rationalize the relative antibacterial, antiplasmodial, and cytotoxic activities of a series of proline-free and proline-containing model antimicrobial pep...

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Autors principals: Vermeer, Louic S., Lan, Yun, Abbate, Vincenzo, Ruh, Emrah, Bui, Tam T., Wilkinson, Louise J., Kanno, Tokuwa, Jumagulova, Elmira, Kozlowska, Justyna, Patel, Jayneil, McIntyre, Caitlin A., Yam, W. C., Siu, Gilman, Atkinson, R. Andrew, Lam, Jenny K. W., Bansal, Sukhvinder S., Drake, Alex F., Mitchell, Graham H., Mason, A. James
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Membrane Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464521/
https://ncbi.nlm.nih.gov/pubmed/22869378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359067
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