Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides

We used a combination of fluorescence, circular dichroism (CD), and NMR spectroscopies in conjunction with size exclusion chromatography to help rationalize the relative antibacterial, antiplasmodial, and cytotoxic activities of a series of proline-free and proline-containing model antimicrobial pep...

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Detalhes bibliográficos
Main Authors: Vermeer, Louic S., Lan, Yun, Abbate, Vincenzo, Ruh, Emrah, Bui, Tam T., Wilkinson, Louise J., Kanno, Tokuwa, Jumagulova, Elmira, Kozlowska, Justyna, Patel, Jayneil, McIntyre, Caitlin A., Yam, W. C., Siu, Gilman, Atkinson, R. Andrew, Lam, Jenny K. W., Bansal, Sukhvinder S., Drake, Alex F., Mitchell, Graham H., Mason, A. James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464521/
https://ncbi.nlm.nih.gov/pubmed/22869378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359067
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