Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency

The biosynthesis of coenzyme A (CoA) from pantothenate and the utilization of CoA in essential biochemical pathways represent promising antimalarial drug targets. Pantothenamides, amide derivatives of pantothenate, have potential as antimalarials, but a serum enzyme called pantetheinase degrades pan...

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Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Howieson, Vanessa M., Tran, Elisa, Hoegl, Annabelle, Fam, Han Ling, Fu, Jonathan, Sivonen, Kate, Li, Xiao Xuan, Auclair, Karine, Saliba, Kevin J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118993/
https://ncbi.nlm.nih.gov/pubmed/27645235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01436-16
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