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Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity
Pantothenamides are N-substituted pantothenate derivatives which are known to exert antimicrobial activity through interference with coenzyme A (CoA) biosynthesis or downstream CoA-utilizing proteins. A previous report has shown that replacement of the ProR methyl group of the benchmark N-pentylpant...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5226837/ https://ncbi.nlm.nih.gov/pubmed/24986662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.06.013 |
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