Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides

We used a combination of fluorescence, circular dichroism (CD), and NMR spectroscopies in conjunction with size exclusion chromatography to help rationalize the relative antibacterial, antiplasmodial, and cytotoxic activities of a series of proline-free and proline-containing model antimicrobial pep...

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Détails bibliographiques
Auteurs principaux: Vermeer, Louic S., Lan, Yun, Abbate, Vincenzo, Ruh, Emrah, Bui, Tam T., Wilkinson, Louise J., Kanno, Tokuwa, Jumagulova, Elmira, Kozlowska, Justyna, Patel, Jayneil, McIntyre, Caitlin A., Yam, W. C., Siu, Gilman, Atkinson, R. Andrew, Lam, Jenny K. W., Bansal, Sukhvinder S., Drake, Alex F., Mitchell, Graham H., Mason, A. James
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Membrane Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464521/
https://ncbi.nlm.nih.gov/pubmed/22869378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359067
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